Plenary Session 3: Keynote Address: Mechanistic Insights into OA Pain

Plenary Session

Date/Time: Friday, April 30, 2021 - 1:00 PM to 2:45 PM
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Description:

Chronic Pain in Pre and Post Total Knee Arthroplasty
Based on a new set of experimental, quantitative, pain profiling bed-side tools approximately 40% of the OA patients can be characterized as pain hypersensitive and hence provides the opportunity to stratify and personalize the management regime.  Pain intensity and pain sensitization prior to total knee arthroplasty are some of the important predictive factors for why approximately 16% of the patient develop chronic post-operative pain.  Recently epigenetic modifications are found to make patients more vulnerable to develop chronic post-operative pain.  Revision surgery based on the indication pain will leave 80 % of the patients with more pain and more pain sensitization.  New management regimes are needed for managing chronic post-operative pain after total knee arthroplasty.  

Abstract(s):

  • 49.THE PATIENT ACCEPTABLE SYMPTOM STATE FOR KNEE PAIN - A SYSTEMATIC LITERATURE REVIEW AND META-ANALYSIS
    V. Georgopoulos1, S. Smith1, D. McWilliams1, T. L. Vincent2, F. E. Watt2, D. A. Walsh1, The STEpUP OA Consortium; 1Univ. of Nottingham, Nottingham, United Kingdom, 2Univ. of Oxford, Oxford, United Kingdom

  • 50. A PHASE 2, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF SENOLYTIC MOLECULE UBX0101 IN THE TREATMENT OF PAINFUL KNEE OSTEOARTHRITIS
    N. Lane1, B. Hsu2, J. Visich2, B. Xie2, A. Khan2, J. Dananberg2; 1Univ. of California Davis, Sacramento, CA, 2Unity Biotechnology, Inc., South San Francisco, CA

  • 51. SYSTEMATIC REVIEW AND META-ANALSYIS OF THE PREVALENCE OF NEUROPATHIC-LIKE PAIN AND/OR PAIN SENSITISATION IN PEOPLE WITH KNEE AND HIP OSTEOARTHRITIS
    L. Zolio1, K. Y. Lim2, M. K. Yan1, M. M. Estee3, S. M. Hussain3, F. M. Cicuttini1,3, A. Wluka1,3; 1Alfred Hlth., Melbourne, Australia, 2Monash Univ., Bandar Sunway, Malaysia, 3Monash Univ., Melbourne, Australia

  • 52. THE RELATIONSHIP BETWEEN PAIN AND WALKING DIFFICULTIES IN SHAPING THE WILLINGNESS TO UNDERGO JOINT SURGERY IN PEOPLE WITH HIP OR KNEE OSTEOARTHRITIS
    A. Dell'Isola1, A. Turkiewicz1, T. Jönsson1, O. Rolfson2, L. Dahlberg1, M. Englund1; 1Lund Univ., Lund, Sweden, 2Univ. of Gotheborg, Gotheborg, Sweden

  • 53. PIEZO2 IS EXPRESSED BY INTRA-ARTICULAR SENSORY NEURONS AND CONTRIBUTES TO KNEE JOINT MECHANICAL PAIN
    D. Ren1, S. Ishihara2, J. Li2, R. J. Miller1, A-M. Malfait2, R. E. Miller2; 1Northwestern Univ., Chicago, IL, 2Rush Univ. Med. Ctr., Chicago, IL

  • 54. USING A BIG DATA APPROACH TO EXPLORE IN SITU CHONDROCYTE RESPONSE TO IMPACT LOADING IN ARTICULAR CARTILAGE
    J. Zheng, T. Wyse Jackson, L. A. Fortier, L. J. Bonassar, M. L. Delco, I. Cohen; Cornell Univ., Ithaca, NY

Speaker(s):