Concurrent Session 6: Cytokines in OA

Concurrent Session

Date/Time: Friday, April 30, 2021 - 10:45 AM to 12:45 PM
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Description:

Is IL1 still the “OA Cytokine” 
Interleukin-1 has long been considered an important target in osteoarthritis (OA). However OA animal models have provided discrepant results on anti-IL-1 therapies, perhaps in part reflecting not only different animal models but prophylactic versus therapeutic experiments. Human clinical studies of IL-1 inhibition in OA have also generally been disappointing, though such studies have also had limitations, including issues with study entry characteristics and relatively short-term use of treatments. Recently a posthoc analysis of a large trial of the IL-1 inhibitor canakinumab, in which patients selected for cardiovascular disease and elevated inflammatory markers (but not OA), demonstrated a marked reduction in total joint replacements in all active drug arms. This recent data may warrant reconsideration of the role of interleukin-1 inhibition in OA.

Abstract(s):

  • 43. IN VIVO INVESTIGATION OF DIFFERENTIALLY POLARIZED EXOGENOUS MACROPHAGES IN MURINE OSTEOARTHRITIS M. Chan1,2, W-Y. Cheung1,3, A. Ziyaeyan1,3, R. Rabani1,3, M. Rasti1,3, S. Gabrial1,3, M. Kapoor1,3, S. Viswanathan1,2; 1Osteoarthritis Res. Program, Div. of Orthopedic Surgery, Schroeder Arthritis Inst., Univ. Hlth.Network, Toronto, ON, Canada, 2Inst. of BioMed. Engineering, Univ. of Toronto, Toronto, ON, Canada, 3Krembil Res. Inst., Univ. Hlth.Network, Toronto, ON, Canada

  • 44. BENEFITS OF PHOTOPOLYMERIZABLE HYDROGELS FOR THE EFFECTIVE DELIVERY OF RAAV VECTORS IN HUMAN BONE MARROW DERIVED MESENCHYMAL STEM CELLS
    W. Meng1, J. K. Venkatesan1, R. Beninatto2, D. Galesso2, G. Schmitt1, S. Speicher-Mentges1, H. Madry1, M. Cucchiarini1; 1Saarland Univ., Homburg, Germany, 2Fidia Farmaceutici S.p.A..,, Padua, Italy, Italy

  • 45. SILENCING OF INFLAMMATORY PATHWAYS THROUGH CRISPR CAS9 KNOCKOUT OF TAK1 IN HUMAN CHONDROCYTES
    Angela Bonato MS A. Bonato1, G. Barreto2, M. Zenobi-Wong1; 1ETH Zurich, Zürich, Switzerland, 2Univ. of Helsinki, Helsinki, Finland

  • 46. INJECTABLE HYDROGELS FUNCTIONALIZED WITH ANTIBODY FRAGMENTS AS INTRA-ARTICULAR CYTOKINE SINKS NEUTRALIZING PRO-CATABOLIC CYTOKINE
     L. Zhong, M. Koerselman, L. Karbaat, T. Kamperman, J. Leijten, B. Zoetebier, M. Karperien; Univ. of twente, Enschede, Netherlands

  • 47. TNF-ALPHA INDUCES FGF1 IRES MEDIATED MESSENGER RNA TRANSLATION IN CHONDROCYTES
     G. G. van den Akker1, A. Chabronova1, B. A. Housmans1, D. Surtel1, A. Cremers1, M. Peffers2, M. M. Caron1, T. J. Welting1; 1Maastricht Univ. Med. Ctr.+, Maastricht, Netherlands, 2Univ. of Liverpool, Liverpool, United Kingdom

  • 48. TNF-α ACTIVATES STAT3 SIGNALING AND SENESCENCE IN NP CELLS
    S. Ashraf1, P. Santerre2, R. Kandel1; 1Mount Sinai Hosp., Toronto, ON, Canada, 2Univ. of Toronto, Toronto, ON, Canada

Speaker(s):