Concurrent Session 3: Cartilage Defects and OA Lesions
Date/Time: Thursday, April 29, 2021 - 2:45 PM to 4:45 PM
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Innovative Therapeutic Device to Improve Cartilage Regeneration
The extended life expectancy and the raise of accidental trauma call for an increase of osteoarticular surgical procedures. Arthroplasty, the main clinical option to treat osteoarticular lesions, has limitations and drawbacks. In this manuscript, we test the preclinical safety of the innovative implant ARTiCAR for the treatment of osteoarticular lesions. Thanks to the combination of two advanced therapy medicinal products, a polymeric nanofibrous bone wound dressing and bone marrow-derived mesenchymal stem cells, the ARTiCAR promotes both subchondral bone and cartilage regeneration. In this work, the ARTiCAR shows 1) the feasibility in treating osteochondral defects in a large animal model, 2) the possibility to monitor non-invasively the healing process and 3) the overall safety in two animal models under GLP preclinical standards. Our data indicate the preclinical safety of ARTiCAR according to the international regulatory guidelines; the ARTiCAR could therefore undergo phase I clinical trial.
Followed by abstract presentations.
25. TIME WAITS FOR NO ONE - A PRELIMINARY ANALYSIS OF AN INCEPTION MATCHED-PAIR COHORT STUDY OF YOUTH SPORT KNEE INJURY
C. Y. Le1,2, A. Pajkic3, J. M. Losciale4,2, J. L. Whittaker4,2; 1Faculty of Rehabilitation Med., Univ. of Alberta, Edmonton, AB, Canada, 2Arthritis Res. Canada, Richmond, BC, Canada, 3Faculty of Kinesiology, Sport, and Recreation, Univ. of Alberta, Edmonton, AB, Canada, 4Dept. of Physical Therapy, Faculty of Med., Univ. of British Columbia, Vancouver, BC, Canada
26. TAXONOMIC CHANGES IN THE MICROBIOTA ARE ASSOCIATED WITH CARTILAGE DAMAGE IN A MOUSE MODEL OF HIGH-FAT DIET AND OA
K. H. Collins, D. J. Schwartz, K. L. Lenz, C. A. Harris, F. Guilak; Washington Univ. in St. Louis, St. Louis, MO
27. EVALUATION OF OSTEOARTHRITIS QUESTIONNAIRE CHECK LIST TO SELECT PAIN THAT CAN BE ALLEVIATED WITH EXERCISE IN PATIENTS WITH HIP OSTEOARTHRITIS AND HARRIS HIP SCORE BELOW 60 POINTS
T. Tsunoda1, K. Hayashi2, Y. Tobo2, F. Ichikawa1; 1Asama Gen. Hosp., Saku, Nagano, Japan, 2Fukuoka Wajiro Hosp., Fukuoka-city, Fukuoka, Japan
28. PAIN HIGHLY CORRELATES TO COLLAGENASE-INDUCED OA-LIKE DAMAGE IN FEMALE MICE BUT NOT IN MALES.
N. Valdrighi, A. B. Blom, H. M. van Beuningen, M. M. Helsen, B. Walgreen, E. L. Vitters, M. I. Koenders, P. M. van der Kraan, F. A. van de Loo, E. Blaney-Davidson; Radboudumc, Nijmegen, Netherlands
29. RESTORING REDOX BALANCE IN CARTILAGE FOLLOWING INJURY RESTORES RETINOIC ACID LEVELS AND PREVENTS MECHANOFLAMMATION
P. Kamalathevan, L. Zhu, T. L. Vincent, D. Furniss; Univ. of Oxford, Oxford, United Kingdom
30. EFFECT OF SYSTEMICALLY DELIVERED ZOLEDRONIC ACID ON JOINT DAMAGE, NOCICEPTIVE KNEE INNERVATION AND PAIN AFTER DESTABILIZATION OF THE MEDIAL MENISCUS IN MICE
A. Obeidat, S. Ishihara, R. Miller, A. Malfait; Rush Univ. Med. center, CHICAGO, IL