Concurrent Session 10: Tissue Interaction in OA

Concurrent Session

Date/Time: Saturday, May 1, 2021 - 10:45 AM to 12:45 PM
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Description:

Hypertension Meets Osteoarthritis - Revisit to Vascular Aetiology

  • Epidemiologically, blood pressure has been linked with radiographic and symptomatic knee osteoarthritis although conflicting results were reported. 
  • At tissue level, systemic hypertension contributes to subchondral bone ischemia and perfusion abnormality that disrupt angiogenic-osteogenic coupling in bone remodelling. 
  • At molecular level, systemic hypertension activates local renin-angiotensin and endothelin system, which may share pathological canonical WNT/-catenin pathway, to induce chondrocyte hypertrophy/senescence and cause cartilage degradation. 
  • Anti-hypertensive drugs that demonstrate the chondroprotective effect in posttraumatic osteoarthritis are worthy of further investigation in multifactorial osteoarthritis with comorbid hypertension alike in humans.

Abstract(s):

  • 85. ELEVATED BLOOD FLOW INDICES ASSOCIATE WITH WORSENED KNEE OSTEOARTHRITIS SYMPTOMS AND STRUCTURAL DAMAGES
    R. NI1, Y. Hu2, X. Guo2, C. Yan3, J. Geurts4, C. Wen1; 1The Hong Kong Polytechnic Univ., Hong Kong, Hong Kong, 2Columbia Univ., New York City, NY, 3the Univ. of Hong Kong, Hong Kong, Hong Kong, 4Lausanne Univ. Hosp. (CHUV), Lausanne, Switzerland

  • 86. CHANGES IN THE VASCULAR ENDOTHELIAL GROWTH FACTOR A SPLICING AXIS IN HUMAN SYNOVIUM ARE RELATED TO ARTHRITIS PAIN
    D. Amanitis1, S. Shahtaheri2, D. F. Mcwilliams2, D. A. Walsh2, L. F. Donaldson1; 1Sch. of Life Sci., Univ. of Nottingham, Nottingham, United Kingdom, 2Sch. of Med., Univ. of Nottingham, Nottingham, United Kingdom

  • 87. EVALUATION OF ARTERIAL STIFFNESS IN PATIENTS AFFECTED BY HAND OSTEOARTHRITIS : A CROSS-SECTIONAL STUDY
    C. MARAIS, C. DUFLOS, R. FERREIRA-LOPEZ, S. AOUINTI, E. VANDELLI, H. RASOANAIVO, Y. THOUVENIN, J-P. CRISTOL, G. DU CAILAR, C. JORGENSEN, P. FESLER, Y-M. PERS; CHU Lapyeronie Montpellier, MONTPELLIER, France

  • 88. INTRA-ARTICULAR INJECTION OF MESENCHYMAL STROMAL CELL ENCAPSULATED IN MICRO-MOLDED ALGINATE PARTICLES FOR THE TREATMENT OF POST-TRAUMATIC OSTEOARTHRITIS: PRELIMINARY STUDY IN RABBIT KNEE
    F. NATIVEL1,2, A. SMITH1, M. MARQUIS3, D. RENARD3, O. GAUTHIER4, C. VINATIER1,5, A. des RIEUX6, J. GUICHEUX1,7, C. LE VISAGE1; 1INSERM UMR1229 RMeS, Regenerative Med. and Skeleton, Université de Nantes, ONIRIS, F-44042 Nantes, France, 2CHU Nantes, Pharmacie Centrale, PHU-11, F-44093 Nantes, France, 3UR1268 BIA (BIOPOLYMERES INTERACTIONS ASSEMBLAGES), INRAE, F-44300, Nantes, France, 4ONIRIS Nantes-Atlantic Coll. of Vet. Med., Ctr. de recherche et d'investigation préclinique (CRIP), F-44300, Nantes, France, 5UFR Odontologie, Université Nantes, F-44042 Nantes, France, 6UCLouvain, Louvain Drug Res. Inst., Advanced Drug Delivery and Biomaterials, 1200 Bruxelles, Belgium, 7CHU Nantes, Pharmacie Centrale, PHU-4 OTONN, F-44042 Nantes, France

  • 89. ASSOCIATION BETWEEN POPLITEAL ARTERY WALL THICKNESS AND STRUCTURAL PROGRESSION IN INDIVIDUALS WITH SYMPTOMATIC KNEE OSTEOARTHRITIS
    E. Pontoh1, F. Cicuttini1, S. Hussain1, G. Jones2, C. Hill3, A. Wluka1, A. Tonkin1, C. Ding2, Y. Wang1; 1Monash Univ., Melbourne, Australia, 2Univ. of Tasmania, Hobart, Australia, 3Univ. of Adelaide, Adelaide, Australia

  • 90. SECRETOMES DIFFER BETWEEN PERIPHERAL BLOOD AND BONE MARROW-DERIVED PLATELETS
    R. C. Dregalla, J. A. Herrera, E. J. Donner; Elite Regenerative Stem Cell Specialists, Johnstown, CO

Speaker(s):