Concurrent Session 10: Tissue Interaction in OA

Concurrent Session

Date/Time: Saturday, May 1, 2021 - 10:45 AM to 12:45 PM
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Hypertension Meets Osteoarthritis - Revisit to Vascular Aetiology

  • Epidemiologically, blood pressure has been linked with radiographic and symptomatic knee osteoarthritis although conflicting results were reported. 
  • At tissue level, systemic hypertension contributes to subchondral bone ischemia and perfusion abnormality that disrupt angiogenic-osteogenic coupling in bone remodelling. 
  • At molecular level, systemic hypertension activates local renin-angiotensin and endothelin system, which may share pathological canonical WNT/-catenin pathway, to induce chondrocyte hypertrophy/senescence and cause cartilage degradation. 
  • Anti-hypertensive drugs that demonstrate the chondroprotective effect in posttraumatic osteoarthritis are worthy of further investigation in multifactorial osteoarthritis with comorbid hypertension alike in humans.

Followed by abstract presentations.