Concurrent Session 1: Metabolic Osteoarthritis

Concurrent Session

Date/Time: Thursday, April 29, 2021 - 10:45 AM to 12:45 PM
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Description:

Metabloic Pathways Contributing to OA
Osteoarthritis (OA), the most common form of age-related degenerative whole-joint disease, is primarily characterized by cartilage destruction, as well as by synovial inflammation, osteophyte formation, and subchondral bone remodeling. However, the molecular mechanisms that underlie the pathogenesis of OA are largely unknown. Our research interest is unraveling the molecular mechanisms of OA pathogenesis and developing novel therapeutic targets for the joint diseases focused on transcriptional reprograming and metabolic disorders in OA pathogenesis. This talk will briefly introduce transcriptional networks and reprogramming in chondrocytes during OA pathogenesis. I will then discuss our recent findings of various metabolic disorders in osteoarthritic chondrocytes associated with OA pathogenesis, such as cholesterol metabolism and amino acid metabolism.

Followed by abstract presentations.

Abstract(s):

  • 7. FAT IMPLANTATION IN LIPODYSTROPHIC MICE RESTORES SUSCEPTIBILITY TO JOINT INJURY AND OSTEOARTHRITIS INDEPENDENT OF BODY WEIGHT
    K. H. Collins1, K. L. Lenz1, E. N. Pollitt1, D. Ferguson1, I. Hutson1, L. E. Springer1, A. K. Oestreich1, R. Tang1, Y-R. Choi2, G. A. Meyer1, S. L. Teitelbaum1, C. T. Pham1, C. A. Harris1, F. Guilak1; 1Washington Univ. in St. Louis, St. Louis, MO, 2Yonsei Univ. Hosp., Seoul, Korea, Republic of

  • 8. IDENTIFICATION OF TWO METABOLITE-BASED PHENOTYPES IN PATIENTS WITH LATE-STAGE KNEE OSTEOARTHRITIS
    J. Rockel1, M. Layeghifard1,2, Y. Rampersaud1,3, A. Perruccio1,4, N. Mahomed1,3, J. Davey1,3, K. Syed1,3, R. Gandhi1,3, M. Kapoor1,5; 1Osteoarthritis Res. Program, Div. of Orthopedic Surgery, Schroeder Arthritis Inst., Krembil Res. Inst., Univ. Hlth.Network, Toronto, ON, Canada, 2Program of Genetics & Genome Biology, The Hosp. for Sick Children, Toronto, ON, Canada, Toronto, ON, Canada, 3Dept. of Surgery, Faculty of Med., Univ. of Toronto, Toronto, ON, Canada, 4Dept. of Surgery, Faculty of Med. and Dalla Lana Sch. of Publ. Hlth., Univ. of Toronto, Toronto, ON, Canada, 5Dept. of Surgery, Faculty of Med. and Dept. of Lab. Med. and Pathobiology, Univ. of Toronto,, Toronto, ON, Canada

  • 9.INTEGRATED APPROACH OF META-ANALYSIS AND BIOINFORMATICS TOWARDS ELUCIDATING DISEASE MECHANISMS ASSOCIATED WITH AGE-RELATED KNEE OSTEOARTHRITIS
    H. Iijima1,2, G. Gilmer3,4, K. Wang1, S. Sivakumar1, Y. Matsui5, F. Ambrosio1,6; 1Dept. of Physical Med. and Rehabilitation, Univ. of Pittsburgh, Pittsburgh, PA, 2Japan Society for the Promotion of Sci., Tokyo, Japan, 3Med. Scientist Training Program, Sch. of Med., Univ. of Pittsburgh, Pittsburgh, PA, 4Dept. of Bioengineering, Univ. of Pittsburgh, Pittsburgh, PA, 5BioMed. and Hlth.Informatics Unit, Graduate Sch. of Med., Nagoya Univ., Nagoya, Japan, 6McGowan Inst. for Regenerative Med., Univ. of Pittsburgh, Pittsburgh, PA

  • 10. METABOLOMIC SIGNATURES FOR THE LONGITUDINAL REDUCTION OF MUSCLE STRENGTH OVER 10 YEARS
    S. Werdyani1, D. Aitken2, Z. Gao3, M. Liu1, E. Randell4, P. Rahman5, G. Jones2, G. Zhai1; 1Div. of BioMed. Sci. - Genetics, Faculty of Med., Mem. Univ. of Newfoundland, St. John’s, NL, Canada, 2Menzies Res. Inst., Univ. of Tasmania, Hobart, Tasmania, Australia, 3Div. of Community Hlth.and Humanities, Faculty of Med., Mem. Univ. of Newfoundland, St. John’s, NL, Canada, 4Discipline of Lab. Med., Faculty of Med., Mem. Univ. of Newfoundland, St. John’s, NL, Canada, 5Discipline of Med., Faculty of Med., Mem. Univ. of Newfoundland, St. John’s, NL, Canada

  • 11. EXERCISE MYOKINE COUNTERACTS CHONDROCYTE SENESCENCE AND OSTEOARTHRITIS DEVELOPMENT THROUGH MITOCHONDRIAL METABOLISM REPROGRAMMING
    F-S. Wang, Y-S. Chen, W-S. Lian; Kaohsiung Chang Gung Mem. Hosp., Taiwan, Kaohsiung, Taiwan

  • 12. EFFECT OF HIGH-FAT DIET ON INTEGRATED OSTEOARTHRITIS PHENOTYPE-METABOLOME NETWORK IN EXERCISED MICE
    A. Batushansky1, A. K. Hahn2,3, R. A. Rawle2, E. B. Lopes1, R. K. June2, T. M. Griffin1,4; 1Oklahoma Med. Res. Fndn., Oklahoma City, OK, 2Montana State Univ., Bozeman, MT, 3Carroll Coll., Helena, MT, 4VA Med. Ctr., Oklahoma City, OK

Speaker(s):