Concurrent Session 1: Metabolic Osteoarthritis
Date/Time: Thursday, April 29, 2021 - 10:45 AM to 12:45 PM
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Metabloic Pathways Contributing to OA
Osteoarthritis (OA), the most common form of age-related degenerative whole-joint disease, is primarily characterized by cartilage destruction, as well as by synovial inflammation, osteophyte formation, and subchondral bone remodeling. However, the molecular mechanisms that underlie the pathogenesis of OA are largely unknown. Our research interest is unraveling the molecular mechanisms of OA pathogenesis and developing novel therapeutic targets for the joint diseases focused on transcriptional reprograming and metabolic disorders in OA pathogenesis. This talk will briefly introduce transcriptional networks and reprogramming in chondrocytes during OA pathogenesis. I will then discuss our recent findings of various metabolic disorders in osteoarthritic chondrocytes associated with OA pathogenesis, such as cholesterol metabolism and amino acid metabolism.
Followed by abstract presentations.